Omilock Capsule Dosage/Direction for Use

Omilock Capsules are recommended to be given in the morning and swallowed whole with liquid.
For patients with swallowing difficulties the capsule might be opened and the contents swallowed or suspended in a slightly acidic fluid e.g juice, soured milk, or non-carbonated water. The dispersion should be taken immediately or within 30 minutes. Alternatively patients can suck the capsule and swallow the pellets with liquid. The pellets must not be chewed or crushed.
For duodenal and benign gastric ulcers, the usual dose is 20 mg Omilock once daily. Symptom resolution is rapid. The majority of patients with duodenal ulcer are healed after 4 weeks. The majority of patients with benign gastric ulcer are healed after 8 weeks. In severe cases, the dose may be increased to 40 mg Omilock once daily and healing is usually achieved within 4 weeks.
Long term therapy for patients with a history of recurrent duodenal ulcer is recommended at a dosage of 20 mg Omilock once daily, up to one year.
For the prevention of relapse in patients with duodenal ulcer disease, the recommended dose is Omilock 10 mg once daily. If needed, the dose can be increased to Omilock 20-40 mg daily.
Reflux oesophagitis: The recommended dosage is Omilock 20 mg once daily. Symptom resolution is rapid and in most patients healing occurs within 4 weeks. For those patients who may not be fully healed after the initial course, healing usually occurs during a further 4 weeks treatment period.
In patients with severe reflux oesophagitis, Omilock 40 mg once daily is recommended and healing is usually achieved within 8 weeks.
For the long term management of patients with healed reflux oesophagitis, the recommended dose is Omilock 10 mg once daily. If needed the dose can be increased to Omilock 20-40 mg once daily.
Zollinger-Ellison syndrome: The initial recommended dosage for patients with the Zollinger-Ellison syndrome is 60 mg once daily, but doses in the range 20 to 120 mg (three times) daily may be used; doses above 80 mg should be divided and given twice daily. In such patients treatment with omeprazole is continued as required to keep the condition under control. Zollinger- Ellison syndrome has been treated continuously with omeprazole for more than 5 years.
Helicobacter pylori-associated peptic ulcer disease: The usual dose is omeprazole capsule 40 mg daily with oral amoxycillin 1.5 g daily (given as 750 mg twice daily) for 2 weeks. In clinical studies, daily dose of 1.5 to 2 g of amoxycillin have been used.
Impaired renal function: Dose adjustment is not required in patients with impaired renal function.
Impaired hepatic function: As bioavailability and plasma half-life of Omeprazole are increased in patients with impaired hepatic function, a daily dose of 10-20 mg may be sufficient.